Pro-inflammatory cytokines in cryptoglandular anal fistulas

Prospective multicenter study of a synthetic bioabsorbable anal fistula plug to treat cryptoglandular transsphincteric anal fistulas.

BACKGROUND Although interest in sphincter-sparing treatments for anal fistulas is increasing, few large prospective studies of these approaches have been conducted. OBJECTIVE The study assessed outcomes after implantation of a synthetic bioabsorbable anal fistula plug. DESIGN A prospective, multicenter investigation was performed. SETTING The study was conducted at 11 colon and rectal cen...

[Treatment of complex cryptoglandular anal fistulas. Does it still require an experienced surgeon?].

There is still controversy on the management of complex cryptoglandular fistulas, even after employing the newest, theoretically simple, techniques. A critical review of the literature was performed, in order to clarify the role of the surgeon, where the precarious balance between eradicating sepsis and maintaining anorectal influences the choice. Techniques, such as fistulotomy, immediate sphi...

Pro-inflammatory cytokines in atherosclerosis.

In vitro and in vivo assessment of inhibitory effect of stevioside on pro-inflammatory cytokines

Objective: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  The aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (TNF-α),  interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (P...

Unbalanced Pro-Inflammatory and Anti-Inflammatory Cytokines Ratio and Endometriosis: A Contributive Pathogenic Role?